FTDMP

FTDMP (Flexible Toolkit Dedicated to Multimeric Predictions)

FTDMP is a framework for protein-protein, protein-DNA and protein-RNA docking and scoring. It can be used for biomolecular docking and subsequent scoring, or just for scoring and ranking structural models of biomolecular complexes generated by different structure prediction methods.

The software is available on GitHub, together with it's documentation, including installation and usage instructions.

FTDMP has been tested using protein-protein, protein-DNA and protein-RNA docking benchmarks. The benchmark datasets are available at Zenodo together with docking tables. FTDMP docking results for the benchmarks are also available at Zenodo.

Publications

If you use the FTDMP for your research, please cite the following articles.

FTDMP software, cleaned docking benchmarks and docking results are published here:

• Olechnovič K, Banciul R, Dapkūnas J, Venclovas Č. (2025) FTDMP: A Framework for Protein-Protein, Protein-DNA, and Protein-RNA Docking and Scoring. Proteins. doi: 10.1002/prot.26792. PubMed PMID: 39748638.

Scoring of protein-protein interfaces using the VoroIF-jury algorithm and details of this algorithm are published in our CASP16 article:

• Olechnovič K, Valančauskas L, Dapkūnas J, Venclovas Č. (2023) Prediction of protein assemblies by structure sampling followed by interface-focused scoring. Proteins; 91:1724–1733. doi: 10.1002/prot.26569. PubMed PMID: 37578163.