2024 |
Dapkūnas J, Timinskas A, Olechnovič K, Tomkuvienė M, Venclovas Č. (2024) PPI3D: a web server for searching, analyzing and modeling protein-protein, protein-peptide and protein-nucleic acid interactions. Nucleic Acids Res, 52(W1):W264–W271; doi: 10.1093/nar/gkae278 [PubMed] | |
Manakova E, Golovinas E, Pocevičiūtė R, Sasnauskas G, Silanskas A, Rutkauskas D, Jankunec M, Zagorskaitė E, Jurgelaitis E, Grybauskas A, Venclovas Č, Zaremba M. (2024) The missing part: the Archaeoglobus fulgidus Argonaute forms a functional heterodimer with an N-L1-L2 domain protein. Nucleic Acids Res, 52(5):2530–2545. doi: 10.1093/nar/gkad1241 [PubMed] | |
2023 |
Mogila I, Tamulaitiene G, Keda K, Timinskas A, Ruksenaite A, Sasnauskas G, Venclovas Č, Siksnys V, Tamulaitis G. (2023) Ribosomal stalk-captured CARF-RelE ribonuclease inhibits translation following CRISPR signaling. Science, 382(6674):1036-1041. doi: 10.1126/science.adj2107 | |
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Olechnovič, K, Valančauskas, L, Dapkūnas, J, Venclovas, Č. (2023) Prediction of protein assemblies by structure sampling followed by interface-focused scoring. Proteins, 91(12):1724-1733. doi: 10.1002/prot.26569 | |
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Gromiha MM, Kundrotas P, Marti MA, Venclovas Č, Li M. (2023) Protein recognition and associated diseases. Front Bioinform, 3:1215141. doi: 10.3389/fbinf.2023.1215141 [PubMed] | |
Sasnauskas G, Tamulaitiene G, Druteika G, Carabias A, Silanskas A, Kazlauskas D, Venclovas Č, Montoya G, Karvelis T, Siksnys V. (2023) TnpB structure reveals minimal functional core of Cas12 nuclease family. Nature, 616:384-389. doi: 10.1038/s41586-023-05826-x [PubMed] | |
2022 |
Zaremba M, Dakineviciene D, Golovinas E, Zagorskaitė E, Stankunas E, Lopatina A, Sorek R, Manakova E, Ruksenaite A, Silanskas A, Asmontas S, Grybauskas A, Tylenyte U, Jurgelaitis E, Grigaitis R, Timinskas K, Venclovas Č, Siksnys V. (2022) Short prokaryotic Argonautes provide defence against incoming mobile genetic elements through NAD+ depletion. Nat Microbiol, 7:1857-1869. doi: 10.1038/s41564-022-01239-0 [PubMed] | |
2021 |
Karvelis T, Druteika G, Bigelyte G, Budre K, Zedaveinyte R, Silanskas A, Kazlauskas D, Venclovas Č, Siksnys V. (2021) Transposon-associated TnpB is a programmable RNA-guided DNA endonuclease. Nature; doi: 10.1038/s41586-021-04058-1 [PubMed] | |
Kryshtafovych A, Moult J, Billings WM, Della Corte D, Fidelis K, Kwon S, Olechnovič K, Seok C, Venclovas Č, Won J. (2021) Modeling SARS-CoV2 proteins in the CASP-commons experiment, Proteins; doi: 10.1002/prot.26231 [PubMed] | |
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Igashov I, Olechnovič K, Kadukova M, Venclovas Č, and Grudinin S. (2021) VoroCNN: Deep convolutional neural network built on 3D Voronoi tessellation of protein structures, Bioinformatics; doi: 10.1093/bioinformatics/btab118 [PubMed] | |
Laan M, Kasak L, Timinskas K, Grigorova M, Venclovas Č, Renaux A, Lenaerts T, Punab M. (2021) NR5A1 c.991-1G > C splice-site variant causes familial 46,XY partial gonadal dysgenesis with incomplete penetrance. Clin Endocrinol, 94(4):656-666. doi: 10.1111/cen.14381 [PubMed] | |
2020 |
Gasiunas G, Young JK, Karvelis T, Kazlauskas D, Urbaitis T, Jasnauskaite M, Grusyte MM, Paulraj S, Wang PH, Hou Z, Dooley SK, Cigan M, Alarcon C, Chilcoat ND, Bigelyte G, Curcuru JL, Mabuchi M, Sun Z, Fuchs RT, Schildkraut E, Weigele PR, Jack WE, Robb GB, Venclovas Č, Siksnys V. (2020) A catalogue of biochemically diverse CRISPR-Cas9 orthologs. Nat Commun, 11(1):5512. doi: 10.1038/s41467-020-19344-1 [PubMed] | |
Kazlauskas D, Krupovic M, Guglielmini J, Forterre P, Venclovas Č. (2020) Diversity and evolution of B-family DNA polymerases. Nucleic Acids Res, 48(18):10142–1015. doi: 10.1093/nar/gkaa760 [PubMed] | |
Makarova KS, Timinskas A, Wolf YI, Gussow AB, Siksnys V, Venclovas Č, Koonin EV. (2020) Evolutionary and functional classification of the CARF domain superfamily, key sensors in prokaryotic antivirus defense. Nucleic Acids Res, 48(16):8828-8847. doi: 10.1093/nar/gkaa635 [PubMed] | |
Karvelis T, Bigelyte G, Young JK, Hou Z, Zedaveinyte R, Budre K, Paulraj S, Djukanovic V, Gasior S, Silanskas A, Venclovas Č, Siksnys V. (2020) PAM recognition by miniature CRISPR–Cas12f nucleases triggers programmable double-stranded DNA target cleavage. Nucleic Acids Res, 48(9):5016-5023. doi: 10.1093/nar/gkaa208 [PubMed] | |
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Makarova KS, Wolf YI, Iranzo J, Shmakov SA, Alkhnbashi OS, Brouns SJJ, Charpentier E, Cheng D, Haft DH, Horvath P, Moineau S, Mojica FJM, Scott D, Shah SA, Siksnys V, Terns MP, Venclovas Č, White MF, Yakunin AF, Yan W, Zhang F, Garrett RA, Backofen R, van der Oost J, Barrangou R, Koonin EV. (2020) Evolutionary classification of CRISPR-Cas systems: a burst of class 2 and derived variants. Nat Rev Microbiol, 18:67–83. doi: 10.1038/s41579-019-0299-x [PubMed] | |
Dapkūnas J, Kairys V, Olechnovič K, Venclovas Č. (2020) Template-based modeling of diverse protein interactions in CAPRI rounds 38-45. Proteins, 88(8):939-94. doi: 10.1002/prot.25845 [PubMed] | |
2019 |
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Dapkūnas J, Olechnovič K, Venclovas Č. (2019) Structural modeling of protein complexes: current capabilities and challenges. Proteins, 87(12):1222-1232. doi: 10.1002/prot.25774. [PubMed] | |
Cheng J, Choe MH, Elofsson A, Han KS, Hou J, Maghrabi AHA, McGuffin LJ, Menéndez-Hurtado D, Olechnovič K, Schwede T, Studer G, Uziela K, Venclovas Č, Wallner B. (2019) Estimation of model accuracy in CASP13. Proteins, 87(12):1361-1377. doi: 10.1002/prot.25767. [PubMed] | |
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Olechnovič K, Monastyrskyy B, Kryshtafovych A, Venclovas Č. (2019) Comparative analysis of methods for evaluation of protein models against native structures. Bioinformatics, 35(6):937-944. [PubMed] | |
2018 |
Drabavicius G, Sinkunas T, Silanskas A, Gasiunas G, Venclovas Č, Siksnys V. (2018) DnaQ exonuclease-like domain of Cas2 promotes spacer integration in a type I-E CRISPR-Cas system. EMBO Rep. 19:e45543. [PubMed] | |
Toliusis P, Tamulaitiene G, Grigaitis R, Tuminauskaite D, Silanskas A, Manakova E, Venclovas Č, Szczelkun MD, Siksnys V, Zaremba M. (2018) The H-subunit of the restriction endonuclease CglI contains a prototype DEAD-Z1 helicase-like motor. Nucleic Acids Res. 46(5):2560-2572. [PubMed] | |
Kazlauskas D, Sezonov G, Charpin N, Venclovas Č, Forterre P, Krupovic M. (2018) Novel Families of Archaeo-Eukaryotic Primases Associated with Mobile Genetic Elements of Bacteria and Archaea. J Mol Biol. 430(5):737-750. [PubMed] | |
Dapkūnas J, Olechnovič K, Venclovas Č. (2018) Modeling of protein complexes in CAPRI round 37 using template-based approach combined with model selection. Proteins, 86 Suppl 1:292-301. [PubMed] | |
2017 |
Kazlauskiene M, Kostiuk G, Venclovas Č, Tamulaitis G, Siksnys V. (2017) A cyclic oligonucleotide signaling pathway in type III CRISPR-Cas systems. Science, 357(6351):605-609 [PubMed] | |
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Shemesh K, Sebesta M, Pacesa M, Sau S, Bronstein A, Parnas O, Liefshitz B, Venclovas Č, Krejci L, Kupiec M. (2017) A structure-function analysis of the yeast Elg1 protein reveals the importance of PCNA unloading in genome stability maintenance. Nucleic Acids Res, 45(6):3189-3203 [PubMed] | |
Dapkūnas J, Timinskas A, Olechnovič K, Margelevičius M, Dičiūnas R, Venclovas Č. (2017) The PPI3D web server for searching, analyzing and modeling protein-protein interactions in the context of 3D structures. Bioinformatics, 33(6):935-937 [PubMed] | |
Tamulaitis G, Venclovas Č, Siksnys V. (2017) Type III CRISPR-Cas immunity: major differences brushed aside. Trends Microbiol, 25:49-61 [PubMed] | |
2016 |
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Kazlauskas D, Krupovic M, Venclovas Č. (2016) The logic of DNA replication in double-stranded DNA viruses: insights from global analysis of viral genomes. Nucleic Acids Res, 44:4551-64[PubMed] | |
Kazlauskiene M, Tamulaitis G, Kostiuk G, Venclovas Č, Siksnys V. (2016) Spatiotemporal control of Type III-A CRISPR-Cas immunity: coupling DNA degradation with the target RNA recognition. Mol Cell, 62:295-306 [PubMed] | |
2015 |
Achar YJ, Balogh D, Neculai D, Juhasz S, Morocz M, Gali H, Dhe-Paganon S, Venclovas Č, Haracska L. (2015) Human HLTF mediates postreplication repair by its HIRAN domain-dependent replication fork remodelling. Nucleic Acids Res, 43:10277-91 [PubMed] | |
Baranauskė S, Mickutė M, Plotnikova A, Finke A, Venclovas Č, Klimašauskas S, Vilkaitis G. (2015) Functional mapping of the plant small RNA methyltransferase: HEN1 physically interacts with HYL1 and DICER-LIKE 1 proteins. Nucleic Acids Res, 43:2802-2812 [PubMed] | |
Zilnyte M, Venclovas Č, Zvirbliene A, Pleckaityte M. (2015) The cytolytic activity of vaginolysin strictly depends on cholesterol and is potentiated by human CD59. Toxins, 7:110-128. [PubMed] | |
2014 |
Tamulaitis G, Kazlauskiene M, Manakova E, Venclovas Č, Nwokeoji AO, Dickman MJ, Horvath P, Siksnys V. (2014) Programmable RNA Shredding by the Type III-A CRISPR-Cas System of Streptococcus thermophilus. Mol Cell, 56:506-517. [PubMed] | |
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Olechnovič K, Venclovas Č. (2014) The CAD-score web server: contact area-based comparison of structures and interfaces of proteins, nucleic acids and their complexes. Nucleic Acids Res,42(Web Server issue):W259-W263 [PubMed] NAR Breakthrough Article | |
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Fang J, Nevin P, Kairys V, Venclovas Č, Engen JR, Beuning PJ. (2014) Conformational analysis of processivity clamps in solution demonstrates that tertiary structure does not correlate with protein dynamics. Structure, 22:572-581 [PubMed] | |
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Timinskas K, Balvočiūtė M, Timinskas A, Venclovas Č. (2014) Comprehensive analysis of DNA polymerase III alpha subunits and their homologs in bacterial genomes. Nucleic Acids Res, 42:1393-1413 [PubMed] | |
2013 |
Gopinath K, Venclovas Č, Ioerger TR, Sacchettini JC, McKinney JD, Mizrahi V, Warner DF. (2013) A vitamin B12 transporter in Mycobacterium tuberculosis. Open Biol, 3:120175. [PubMed] | |
Olechnovič K, Kulberkytė E, Venclovas Č. (2013) CAD-score: A new contact area difference-based function for evaluation of protein structural models. Proteins, 81:149–162. [PubMed] | |
2012 |
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Nagirnaja L, Venclovas Č, Rull K, Jonas KC, Peltoketo H, Christiansen OB, Kairys V, Kivi G, Steffensen R, Huhtaniemi IT, Laan M. (2012) Structural and functional analysis of rare missense mutations in human chorionic gonadotropin beta-subunit. Mol Hum Reprod, 18:379-390. [PubMed] Viršelio tema | |
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2011 |
Timinskas K, Venclovas Č. (2011) The N-terminal region of the bacterial DNA polymerase PolC features a pair of domains, both distantly related to domain V of the DNA polymerase III tau subunit.FEBS J, 278:3109-3118. [PubMed] | |
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Olechnovič K, Margelevičius M, Venclovas Č. (2011) Voroprot: an interactive tool for the analysis and visualization of complex geometric features of protein structure. Bioinformatics, 27:723-724.[PubMed] | |
Laganeckas M, Margelevičius M, Venclovas Č. (2011) Identification of new homologs of PD-(D/E)XK nucleases by support vector machines trained on data derived from profile-profile alignments.Nucleic Acids Res, 39:1187-1196. [PubMed] | |
Barsky D, Laurence TA, Venclovas Č. (2011) How proteins slide on DNA. In Biophysics of DNA-protein interactions: From single molecules to biological systems, M.C. Williams and Maher, L.J. III, eds., Springer Science + Business Media, LLC, p.39-68. [Publisher link] | |
2010 |
Warner DF, Ndwandwe DE, Abrahams GL, Kana BD, Machowski EE, Venclovas Č, Mizrahi V. (2010) Essential roles for imuA'- and imuB-encoded accessory factors in DnaE2-dependent mutagenesis in Mycobacterium tuberculosis. Proc Natl Acad Sci USA, 107:13093-13098. [PubMed] | |
Margelevičius M, Laganeckas M, and Venclovas Č. (2010) COMA server for protein distant homology search. Bioinformatics, 26:1905-1906. [PubMed] | |
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Zubrienė A, Gutkowska M, Matulienė J, Chaleckis R, Michailovienė V, Voroncova A, Venclovas Č, Zylicz A, Zylicz M, Matulis D. (2010) Thermodynamics of radicicol binding to human Hsp90 alpha and beta isoforms. Biophys Chem, 152:153-163. [PubMed] | |
2009 |
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2008 |
McCauley MJ, Shokri L, Sefcikova J, Venclovas Č, Beuning PJ, Williams M. (2008) Distinct double- and single-stranded DNA binding of E. coli replicative DNA polymerase III alpha subunit. ACS Chem Biol, 3:577-587. [ PubMed] | |
Repšys V, Margelevičius M, and Venclovas Č. (2008) Re-searcher: a system for recurrent detection of homologous protein sequences. BMC Bioinformatics, 9:296. [PubMed] | |
2007 |
Jurėnaitė-Urbanavičienė S, Šerkšnaitė J, Kriukienė E, Giedrienė J, Venclovas Č, Lubys A. (2007) Generation of DNA cleavage specificities of type II restriction endonucleases by reassortment of target recognition domains. Proc Natl Acad Sci USA, 104:10358-10363. [PubMed] | |
Sukackaite R, Lagunavicius A, Stankevicius K, Urbanke C, Venclovas Č, Siksnys V. (2007) Restriction endonuclease BpuJI specific for the 5'-CCCGT sequence is related to the archaeal Holliday junction resolvase family. Nucleic Acids Res., 35:2377-2389. [PubMed] | |
2006 |
Shi G, Chang DY, Cheng CC, Guan X, Venclovas Č, Lu A-L. (2006) Physical and functional interactions between MutY homolog (MYH) and checkpoint proteins Rad9-Rad1-Hus1. Biochem J., 400:53-62. [PubMed] | |
2005 |
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Venclovas Č, Margelevičius M. (2005) Comparative modeling in CASP6 using consensus approach to template selection, sequence-structure alignment and structure assessment. Proteins, 61 Suppl 7:99-105. [PubMed] | |
Kryshtafovych A, Venclovas Č, Fidelis K, Moult J. (2005) Progress over the first decade of CASP experiments. Proteins, 61 Suppl 7:225-36. [PubMed] | |
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2004 |
Daujotytė D, Serva S, Vilkaitis G, Merkienė E, Venclovas Č, Klimašauskas S. (2004) HhaI DNA methyltransferase uses the protruding Gln237 for active flipping of its target cytosine. Structure, 12:1047-55. [PubMed] | |
Venclovas Č, Ginalski K, Kang C. (2004) Sequence-structure mapping errors in the PDB: OB-fold domains. Protein Sci, 13:1594-1602. [PubMed] | |
2003 |
Venclovas Č. (2003) Comparative modeling in CASP5: progress is evident, but alignment errors remain a significant hindrance. Proteins, 53, Suppl 6: 380-388. [PubMed] | |
Venclovas Č, Zemla A, Fidelis K, Moult J. (2003) Assessment of progress over the CASP experiments. Proteins, 53, Suppl 6:585-595. [PubMed] | |
Winthrop MD, DeNardo SJ, Albrecht H, Mirick GR, Kroger LA, Lamborn KR, Venclovas Č, Colvin ME, Burke PA, DeNardo GL. (2003) Selection and characterization of anti-MUC-1 scFvs intended for targeted therapy. Clinical Cancer Research, 9 (10 Pt 2):3845S-3853S. [PubMed] | |
2002 |
Venclovas Č, Colvin ME, Thelen MP. (2002) Molecular modeling-based analysis of interactions in the RFC-dependent clamp-loading process. Protein Sci., 11: 2403-2416. [PubMed] | |
Bitinaitė J, Mitkaitė G, Daukšaitė V, Jakubauskas A, Timinskas A, Vaišvila R, Lubys A, Janulaitis A. (2002) Evolutionary relationship of Alw26I, Eco31I and Esp3I, restriction endonucleases that recognise overlapping sequences. Mol Genet Genomics, 267:664-672. [PubMed] | |
Vilkaitis G, Lubys A, Merkienė E, Timinskas A, Janulaitis A, Klimašauskas S. (2002) Circular permutation of DNA cytosine-N4 methyltransferases: in vivo coexistence in the BcnI system and in vitro probing by hybrid formation. Nucleic Acids Res. 30:1547-1557 [PubMed] | |
2001 |
Venclovas Č, Zemla A, Fidelis K, Moult J. (2001) Comparison of performance in successive CASP experiments. Proteins, Suppl. 5:163-170 [PubMed] | |
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Zemla A, Venclovas Č, Moult J, Fidelis K. (2001) Processing and Evaluation of Predictions in CASP4. Proteins, Suppl. 5:13–21. [PubMed] | |
Česnavičienė E, Petrušytė M, Kazlauskienė R, Manelienė Z, Timinskas A, Lubys A, Janulaitis A. (2001) Characterization of AloI, a restriction-modification system of a new type. J Mol Biol. 314:205-216. [PubMed] | |
Vitkutė J, Stankevičius K, Tamulaitienė G, Manelienė Z, Timinskas A, Berg DE, Janulaitis A. (2001) Specificities of eleven different DNA methyltransferases of Helicobacter pylori strain 26695. J Bacteriol. 183:443-450.[PubMed] | |
2000 |
Ginalski K, Venclovas Č, Lesyng B, Fidelis K. (2000) Structure-based sequence alignment for the beta-trefoil sub-domain of the clostridial neurotoxin family provides residue level information about the putative ganglioside binding site. FEBS Lett., 482:119-124. [PubMed] | |
Venclovas Č, Thelen M. (2000) Structure-based predictions of Rad1, Rad9, Hus1 and Rad17 participation in sliding clamp and clamp-loading complexes. Nucleic Acids Res., 28:2481-2493.[PubMed] | |
1999 |
Venclovas Č, Ginalski K, Fidelis K. (1999) Addressing the issue of sequence-to-structure alignments in comparative modeling of CASP3 target proteins. Proteins, Suppl. 3:73-80. [PubMed] | |
Venclovas Č, Zemla A, Fidelis K, Moult J. (1999) Some measures of comparative performance in the three CASPs. Proteins, Suppl. 3: 231-237. [PubMed] | |
Zemla A, Venclovas Č, Moult J, Fidelis K. (1999) Processing and Analysis of CASP3 Protein Structure Predictions. Proteins, Suppl. 3:22-29. [PubMed] | |
Thelen M, Venclovas Č, Fidelis K. (1999) A sliding clamp model for the Rad1 family of cell cycle checkpoint proteins. Cell, 96:769-770. [PubMed] | |
Zemla A, Venclovas Č, Fidelis K, Rost B. (1999) A modified definition of Sov, a segment based measure for protein secondary structure prediction assessment. Proteins, 34:220-223. [PubMed] | |